Diabetic gangrene is the most severe and life-threatening complication of diabetic foot syndrome. It develops as a result of chronic and extensive vascular damage caused by persistently elevated blood glucose levels, which deprive tissues of oxygen and essential nutrients. Medinstitute Nikolenko Clinic has more than 35 years of clinical experience and expertise in the treatment of diabetic foot conditions. Our primary medical objective is early intervention during the stage of diabetic angiopathy, before irreversible tissue necrosis develops.

When proper nutrition is neglected and blood sugar levels remain elevated for many years, excess glucose contributes to metabolic changes that gradually impair the function of small arteries and capillaries. Due to their anatomical distance from the heart, the lower extremities are often among the first areas affected by severe ischemia and hypoxia (oxygen deprivation). Gangrene may appear suddenly, with characteristic blackening of the toes or the development of dark necrotic lesions on the heels. Without prompt medical attention and restoration of adequate tissue oxygenation and circulation, the condition can ultimately lead to amputation.

Our Ozone Therapy Treatment Protocol

The primary therapeutic goal in preserving an affected limb is the rapid and effective restoration of oxygen delivery to compromised tissues. At our clinic, we utilize a comprehensive ozone therapy protocol that combines both systemic (internal) and local (external) approaches.

• Advanced 10-Pass Method (Herrmann – Germany)

The 10-Pass Method is one of the most widely recognized forms of intravenous ozone therapy. During this controlled procedure, the patient’s blood is repeatedly exposed to a medical oxygen-ozone mixture under carefully monitored conditions. The protocol is designed to support microcirculation, optimize blood flow characteristics, and stimulate physiological regenerative processes.

• Local Ozone Bagging Therapy

The affected limb is enclosed in a specialized airtight medical-grade bag into which an oxygen-ozone mixture is introduced. This localized treatment is intended to support wound care, reduce microbial burden on the skin surface, and promote a favorable environment for tissue repair and healing.

• Systemic Oxygenation and Blood Flow Support

Intravenous ozone therapy is used with the aim of enhancing oxygen transport and improving microcirculatory function. These effects may help improve oxygen delivery to tissues experiencing reduced blood supply.

Stages of Diabetic Angiopathy Progressing to Gangrene

Diabetic gangrene does not develop overnight. It represents the final stage of a prolonged process of vascular deterioration that typically progresses through the following stages:

1. Hyperglycemia and Endothelial Damage

Chronically elevated blood glucose levels damage the inner lining of blood vessels (the endothelium), leading to ongoing inflammation and vascular dysfunction.

2. Microangiopathy

Excess glucose and its metabolic by-products contribute to narrowing and damage of the small blood vessels supplying the lower limbs, kidneys, and eyes.

3. Ischemia and Hypoxia

Blood flow becomes significantly reduced. The feet may remain persistently cold, pain may occur even at rest, and wounds heal slowly or fail to heal altogether.

4. Tissue at Risk (Pre-Gangrene Stage)

Dark spots may appear on the heels, while the toes can develop a bluish discoloration, indicating the onset of severe tissue compromise.

5. Established Gangrene (Necrosis)

Tissues become blackened and die. At this stage, there is a substantial risk of serious infection and sepsis. Without urgent medical intervention, amputation may become necessary.

Why Choose Medinstitute Nikolenko Clinic?

• More Than 35 Years of Clinical Experience

We have extensive experience in managing complex and advanced cases of diabetic foot complications and vascular disorders associated with diabetes.

• Advanced Ozone Therapy Technologies

Our clinic utilizes modern, certified ozone therapy techniques designed to support circulation, tissue oxygenation, and wound management.

• Comprehensive Treatment Approach

We address both the systemic causes of vascular impairment and the local manifestations of the condition through an integrated therapeutic strategy.

• Relapse Prevention Program

Following stabilization of the patient’s condition, we develop individualized maintenance plans that include regular monitoring, metabolic control, and guidance on nutrition and lifestyle modifications.

• Multidisciplinary, Patient-Centered Care

Our team of medical professionals provides comprehensive care that focuses not only on the affected limb but also on protecting other organs commonly impacted by diabetes, including the kidneys, heart, and brain.